Article
Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2011
Chung Chiung-yin, Bien Harold, Sobie Eric A, Dasari Vikram, McKinnon David, Rosati Barbara, Entcheva Emilia
Abstract excerpt
In vitro models of cardiac hypertrophy focus exclusively on applying "external" dynamic signals (electrical, mechanical, and chemical) to achieve a hypertrophic state. In contrast, here we set out to demonstrate the role of "self-organized" cellular architecture and activity in reprogramming card...
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