Article
Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation.
Biofabrication - 12 Mar 2021
Kit-Anan Worrapong, Mazo Manuel M, Wang Brian X, Leonardo Vincent, Pence Isaac J, Gopal Sahana, Gelmi Amy, Nagelkerke Anika, Becce Michele, Chiappini Ciro, Harding Sian E, Terracciano Cesare M, Stevens Molly M
Abstract excerpt
Traditional in vitro bioengineering approaches whereby only individual biophysical cues are manipulated at any one time are highly inefficient, falling short when recapitulating the complexity of the cardiac environment. Multiple biophysical cues are present in the native myocardial niche and are essential during development, as well as in maintenance of adult cardiomyocyte (CM) phenotype in both health and...
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