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Article

Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026

Garoña Ana, Lemos Morgane V, Giometto Andrea, Fumasoni Marco

Abstract excerpt

Cell volume, a key determinant of physiology, is maintained by cell size homeostasis. Large deviations from typical size are often harmful, yet cell sizes have diverged drastically during evolution. How size homeostasis evolves to support such diversity without impairing cellular function remains unclear. To address this question, we used experimental evolution to progressively select for smaller Saccharomyces...

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Identifiers

PMID: 42284327
DOI: 10.1073/pnas.2531280123
PMCID: PMC13273275

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