Article

Genetic compensation is triggered by mutant mRNA degradation

2018-05-22

Abstract excerpt

Genetic compensation by transcriptional modulation of related gene(s) (also known as transcriptional adaptation) has been reported in numerous systems 1–3 ; however, whether and how such a response can be activated in the absence of protein feedback loops is unknown. Here, we develop and analyze several models of transcriptional adaptation in zebrafish and mouse that we show are not caused by loss of protein func...

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Literature Corpus work: 437d0cb8-89db-58c7-9709-b25cffc93443
DOI: 10.1101/328153

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