Article

Genetic compensation in β-actin mutants occurs independently of mutations that destabilize β-actin mRNA

2026-04-24

Abstract excerpt

Proper maintenance of gene expression in response to mutations or environmental fluctuations is critical for cell development and survival. Recently, a novel genetic compensation mechanism was described wherein mutant mRNA decay triggers increased transcription of paralogous genes. This effect was reported for several genes, including β-actin ( Actb ) in mouse embryonic stem cells, where Actb mRNA with a prematu...

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Literature Corpus work: 73054a55-0005-55af-924e-34688051beed
DOI: 10.64898/2026.04.21.719943

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