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Article

mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay.

PLoS genetics - 1 Nov 2017

Anderson Jennifer L, Mulligan Timothy S, Shen Meng-Chieh, Wang Hui, Scahill Catherine M, Tan Frederick J, Du Shao J, Busch-Nentwich Elisabeth M, Farber Steven A

Abstract excerpt

As model organism-based research shifts from forward to reverse genetics approaches, largely due to the ease of genome editing technology, a low frequency of abnormal phenotypes is being observed in lines with mutations predicted to lead to deleterious effects on the encoded protein. In zebrafish, this low frequency is in part explained by compensation by genes of redundant or similar function, often resulting...

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PMID: 29161261
DOI: 10.1371/journal.pgen.1007105
PMCID: PMC5716581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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