Parental mutations influence wild-type offspring via transcriptional adaptation.

doi:10.1126/sciadv.abj2029

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Article

Parental mutations influence wild-type offspring via transcriptional adaptation.

Science advances - 25 Nov 2022

Jiang Zhen, El-Brolosy Mohamed A, Serobyan Vahan, Welker Jordan M, Retzer Nicholas, Dooley Christopher M, Jakutis Gabrielius, Juan Thomas, Fukuda Nana, Maischein Hans-Martin, Balciunas Darius, Stainier Didier Y R

Abstract excerpt

Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of physiological or environmental factors. Here, we show intergenerational and transgenerational inheritance of transcriptional adaptation (TA), a process whereby mutant messenger RNA (mRNA) degradation affects gene expression, in nematodes and zebrafish. Wild-type offspring of animals heterozygous for mRNA-destabilizing alleles...

Topics

Animals
Zebrafish
Acclimatization
Heterozygote
Mutation
RNA, Messenger

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Identifiers

PMID: 36427314
DOI: 10.1126/sciadv.abj2029
PMCID: PMC9699682

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