Article
Transcriptional adaptation in Caenorhabditis elegans.
eLife - 17 Jan 2020
Serobyan Vahan, Kontarakis Zacharias, El-Brolosy Mohamed A, Welker Jordan M, Tolstenkov Oleg, Saadeldein Amr M, Retzer Nicholas, Gottschalk Alexander, Wehman Ann M, Stainier Didier Yr
Abstract excerpt
Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed that the mutant mRNA, rather than the loss of protein function, activates this response. While several examples of transcriptional adaptation have been reported in zebrafish embryos and in mouse...
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