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Article

Induction of a transcriptional adaptation response by RNA destabilization events.

EMBO reports - 1 May 2025

Xie Lihan, Jakutis Gabrielius, Dooley Christopher M, Guenther Stefan, Kontarakis Zacharias, Howard Sarah P, Juan Thomas, Stainier Didier Y R

Abstract excerpt

Transcriptional adaptation (TA) is a cellular process whereby mRNA-destabilizing mutations are associated with the transcriptional upregulation of so-called adapting genes. The nature of the TA-triggering factor(s) remains unclear, namely whether an mRNA-borne premature termination codon or the subsequent mRNA decay process, and/or its products, elicits TA. Here, working with mouse Actg1, we first establish two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40128410
DOI: 10.1038/s44319-025-00427-3
PMCID: PMC12069562

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