Article

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mechanisms underlying Doxorubicin (Doxo) chemotherapy-induced aortic stiffening are incompletely understood. <h4>Objectives</h4> Determine the role of cellular senescence and the senescence-associated secretory phenotype (SASP) in mediating Doxo-induced aortic stiffening and the influence of senolytic therapy. <h4>Methods</h4> Aortic stiffness (aortic pulse-wave velocity [...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4369a4b0-7337-5b12-b48c-eb84fee9347b
DOI: 10.1101/2025.05.13.653823

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation StressDOI 10.1101/2025.05.13.653823Read

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic TreatmentSemantic proximity Read

Stiffness Drives Endothelial Senescence and Inflammation in Aging and Doxorubicin-Induced Vascular DysfunctionSemantic proximity Read

The Role of the Senescence-Associated Secretory Phenotype in Cardiovascular Disease Among the ElderlySemantic proximity Read

Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic AneurysmsSemantic proximity Read

Matrix stiffness induces endothelial network senescenceSemantic proximity Read

Analysis of intracellular fatty acid metabolism during Doxorubicin induced senescence of MCF7 cells using Raman ImagingSemantic proximity Read

Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic AortaSemantic proximity Read

Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease.Semantic proximity Read

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblastsSemantic proximity Read

Sox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffnessSemantic proximity Read

PET-Microplastics Trigger Endothelial Glycocalyx Loss via ER Stress and ROS Unleashing IL-1β-Driven SMC Switching and Early Aortic Structural ImpairmentSemantic proximity Read

Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.Semantic proximity Read