Article

Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in Chronic Kidney Disorder induced Vascular Calcification

2025-04-26

Abstract excerpt

<h4>Background</h4> Chronically high levels of phosphate (P) in the serum caused by chronic kidney disease (CKD) induce osteogenic changes in the aortic Vascular Smooth Muscle Cells (VSMCs). Premature onset of cellular senescence is observed in these phenotypically transitioned cells, which plays a critical role in pathology of vascular calcification. We have previously shown that EDTA therapy can remove calcium...

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Literature Corpus work: 2e411794-34e8-52bb-8d28-f0e0dd5eb153
DOI: 10.1101/2025.04.23.650230

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