Article

Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta

2025-06-15

Abstract excerpt

This study investigated the role of mitochondrial function in aortic aging. As the aorta ages, it becomes stiffer and less compliant, increasing the risk of aneurysmal disease, hypertension, and diastolic dysfunction. Given the role of mitochondrial dysfunction in non-age related aortopathies and as a hallmark of aging, we investigated its contribution to the aging aorta. Both male and female young (5-6 month) and...

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Literature Corpus work: 8f4a562d-6a99-593c-a793-3cad032fee4a
DOI: 10.1101/2025.06.13.659620

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