Article

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic Treatment

2025-04-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mechanisms underlying Doxorubicin (Doxo) chemotherapy-induced vascular endothelial dysfunction are incompletely understood. <h4>Objectives</h4> Determine the role of cellular senescence in mediating Doxo-induced vascular endothelial dysfunction and the influence of senolytic therapy as a therapeutic strategy to mitigate endothelial dysfunction with Doxo. <h4>Methods</h4> E...

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Literature Corpus work: 9664db2a-92c0-550f-a81b-785d01aabeff
DOI: 10.1101/2025.04.19.649672

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