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Article

Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease.

Journal of vascular research - 1 Jan 2018

Riches Kirsten, Clark Emily, Helliwell Rebecca J, Angelini Timothy G, Hemmings Karen E, Bailey Marc A, Bridge Katherine I, Scott D Julian A, Porter Karen E

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a silent, progressive disease with a high mortality and an increasing prevalence with aging. Smooth muscle cell (SMC) dysfunction contributes to gradual dilatation and eventual rupture of the aorta. Here we studied phenotypic characteristics in SMC cultured from end-stage human AAA (≥5 cm) and cells cultured from a porcine carotid artery (PCA) model of early and end-stage...

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Share to Aorta, Abdominal
Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dilatation, Pathologic

Share to Muscle, Smooth

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 29232676
DOI: 10.1159/000484088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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