Article

Significant improvement of reprogramming efficiency by transient overexpression of ZGA inducer Dux but not Dppa2/4

2019-10-13

Abstract excerpt

Cloned animal have been reported by somatic cell nuclear transfer (SCNT) for many years. However, the SCNT is extremely inefficient, and zygotic genome activation (ZGA) is required for SCNT and chemical mediated reprogramming. To identify candidate factors that facilitate ZGA in reprogramming, we performed siRNA-repressor and mRNA-inducer screening, which revealed Dux, Dppa2, and Dppa4 as key factors enhancing the...

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Literature Corpus work: 4361d051-7f98-5f97-8dac-20882fa61f4b
DOI: 10.1101/803593

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