Article

Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer Embryo

2018-08-14

Abstract excerpt

Despite the success of the production of animals by somatic cell nuclear transfer (SCNT) in many species, the method is limited by a low efficiency. After zygotic genome activation (ZGA), a large number of endogenous retroviruses (ERVs) are expressed, including the murine endogenous retrovirus-L (MuERVL/MERVL). In this study, we generated a series of MERVL-reporter mouse strains to detect the ZGA event in embryos....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a58a8651-e238-53ab-a688-c034cc8ae6f3
DOI: 10.1101/390484

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fine Tuning of Histone Demethylase KDM6A/B Improves the Development of Nuclear Transfer EmbryoDOI 10.1101/390484Read

Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencingSemantic proximity Read

Characterization of transcriptional activity during ZGA in mammalian SCNT embryoSemantic proximity Read

Strategies to Improve the Efficiency of Somatic Cell Nuclear TransferSemantic proximity Read

KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter systemSemantic proximity Read

Significant improvement of reprogramming efficiency by transient overexpression of ZGA inducer Dux but not Dppa2/4Semantic proximity Read

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A.Semantic proximity Read

Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic DevelopmentSemantic proximity Read

Epigenetic manipulation to improve mouse SCNT embryonic developmentSemantic proximity Read

Transient JMJD2B-Mediated Reduction of H3K9me3 Levels Improves Reprogramming of Embryonic Stem Cells into Cloned EmbryosSemantic proximity Read

Epigenetic Reprogramming During Somatic Cell Nuclear Transfer: Recent Progress and Future DirectionsSemantic proximity Read

H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogrammingSemantic proximity Read

Epigenetic reprogramming in mammalian nuclear transferSemantic proximity Read