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Epigenetic Reprogramming During Somatic Cell Nuclear Transfer: Recent Progress and Future Directions

18 Mar 2020

Abstract excerpt

Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in livestock and also describe mice data for reference. This review presents the factors contributing to low cloning efficiency, demonstrates that incomplete epigenetic reprogramming leads to the low developmental potential of cloned...

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PMID: 32256519
DOI: 10.3389/fgene.2020.00205

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