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Strategies to Improve the Efficiency of Somatic Cell Nuclear Transfer

10 Feb 2022

Abstract excerpt

Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian species have been successfully cloned, the majority of cloned embryos failed to develop to term, resulting in the overall cloning efficiency being still low. There are many factors contributing to the cloning success. Aberrant...

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PMID: 35216087
DOI: 10.3390/ijms23041969

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