Article
DUX is a non-essential synchronizer of zygotic genome activation.
Development (Cambridge, England) - 23 Jan 2020
De Iaco Alberto, Verp Sonia, Offner Sandra, Grun Delphine, Trono Didier
Abstract excerpt
Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the one- to two-cell stage in the mouse impairs EGA and blastocyst maturation. Here, we demonstrate that mice carrying homozygous Dux deletions display markedly reduced expression of DUX target genes and...
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