Article

Dyrk1a is required for craniofacial development in <i>Xenopus laevis</i>

2024-01-14

Abstract excerpt

Loss of function mutations in the dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene are associated with craniofacial malformations in humans. Here we characterized the effects of deficient DYRK1A in craniofacial development using a developmental model, Xenopus laevis . Dyrk1a mRNA and protein was expressed throughout the developing head and was enriched in the branchial arches which con...

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Literature Corpus work: 433e06c2-18b5-5f15-8c5a-b66da9aa9406
DOI: 10.1101/2024.01.13.575394

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