Article

<i>Ripply3</i> overdosage induces mid-face shortening through <i>Tbx1</i> downregulation in Down syndrome models

2024-09-15

Abstract excerpt

<h4>ABSTRACT</h4> The most frequent and unique features of Down syndrome (DS) are learning disability and ucraniofacial (CF) dysmorphism. The DS-specific CF features are an overall reduction in head dimensions (microcephaly), relatively wide neurocranium (brachycephaly), reduced mediolaterally orbital region, reduced bizygomatic breadth, small maxilla, small mandible, and increased individual variability. Until n...

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Literature Corpus work: 130ffdc4-a5f4-5585-8ce5-c43004a4c232
DOI: 10.1101/2024.09.13.612914

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