Article

The Role of Goldilocks Protein Kinase DYRK1A in Embryonic Development

2025-04-14

Abstract excerpt

DYRK1A (Dual-specificity Tyrosine (Y) Regulated Kinase) is a dosage sensitive gene where too much or too little of its “Goldilocks” protein product can result in structural birth defects. DYRK1A loss of function variants are associated with DYRK1A syndrome, which is characterized by intellectual disability and stereotypical craniofacial anomalies. DYRK1A is located on chromosome 21 and increased dosage...

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Literature Corpus work: 2b26154c-469f-5a84-818e-c92079efebca
DOI: 10.20944/preprints202504.1118.v1

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