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Article

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos.

Development (Cambridge, England) - 22 Jun 2020

Willsey Helen Rankin, Xu Yuxiao, Everitt Amanda, Dea Jeanselle, Exner Cameron R T, Willsey A Jeremy, State Matthew W, Harland Richard M

Abstract excerpt

DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is a high-confidence autism risk gene that encodes a conserved kinase. In addition to autism, individuals with putative loss-of-function variants in DYRK1A exhibit microcephaly, intellectual disability, developmental delay and/or congenital anomalies of the kidney and urinary tract. DYRK1A is also located within the critical region for...

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Identifiers

PMID: 32467234
DOI: 10.1242/dev.189290
PMCID: PMC10755402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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