Transient expression of <i>Mnb/Dyrk1a</i> couples cell cycle exit and differentiation of neuronal precursors by inducing <i>p27KIP1</i> expression and suppressing NOTCH signaling

Abstract excerpt

The decision of a neural precursor to stop dividing and begin its terminal differentiation at the correct place, and at the right time, is a crucial step in the generation of cell diversity in the nervous system. Here, we show that the Down's syndrome candidate gene (Mnb/Dyrk1a) is transiently expressed in prospective neurons of vertebrate CNS neuroepithelia. The gain of function (GoF) of Mnb/Dyrk1a induced...

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