Article
Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk.
Nature genetics - 1 Aug 2000
Halford M M, Armes J, Buchert M, Meskenaite V, Grail D, Hibbs M L, Wilks A F, Farlie P G, Newgreen D F, Hovens C M, Stacker S A
Abstract excerpt
Secondary palate formation is a complex process that is frequently disturbed in mammals, resulting in the birth defect cleft palate. Gene targeting has identified components of cytokine/growth factor signalling systems such as Tgf-alpha/Egfr, Eph receptors B2 and B3 (Ephb2 and Ephb3, respectively), Tgf-beta2, Tgf-beta3 and activin-betaA (ref. 3) as regulators of secondary palate development. Here we demonstrate...
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