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Article

Dkk1 inhibition restores mandibular growth in an achondroplasia mouse model.

Biology open - 15 Mar 2026

Raveendranathan Briantana, Estibals Valentin, Pulido Eric, Lemoine Clara, Kaci Nabil, Pereur Rachel, Zarhrate Mohammed, Dupichaud Sébastien, Dambroise Emilie, Legeai-Mallet Laurence, Biosse Duplan Martin

Abstract excerpt

Meckel's and condylar cartilages are key to mandible development, with Meckel's cartilage acting as a template and condylar cartilage as a growth center. In achondroplasia, the most common form of genetic dwarfism, abnormalities of these cartilages lead to micrognathia, with significant functional repercussions for affected individuals. How FGFR3 overactivation in achondroplasia disrupts Meckel's and condylar...

Read the complete abstract on PubMed

Topics

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Share to Achondroplasia
Share to Cartilage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chondrocytes

Share to Gene Expression Regulation, Developmental

Share to Intercellular Signaling Peptides and Proteins

Share to Mandible

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 41954527
DOI: 10.1242/bio.062540
PMCID: PMC13094333

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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