Article

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell therapy applications

2022-11-01

Abstract excerpt

<h4>ABSTRACT</h4> Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients. Determining the fate of T cells following patient infusion hinges on the ability to track them in vivo . While this is possible by genetic labeling of parent cells, the applicability of this approach has been l...

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Literature Corpus work: 432c7111-22de-532f-8fd7-4b443a78835e
DOI: 10.1101/2022.10.31.514542

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