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Engineering strategies to safely drive CAR T-cells into the future

19 Jun 2024

Abstract excerpt

Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer treatment in the last decade, giving unprecedented results against hematological malignancies. All approved CAR T-cell products, as well as many being assessed in clinical trials, are generated using viral vectors to deploy the exogenous genetic material into T-cells. Viral vectors have a long-standing clinical history in gene...

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CAR-T cell therapy research
CRISPR and Genetic Engineering
Virus-based gene therapy research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38962002
DOI: 10.3389/fimmu.2024.1411393

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