Article

Fast, efficient and virus-free generation of <i>TRAC</i> -replaced CAR T cells

2021-02-14

Abstract excerpt

Chimeric Antigen Receptor (CAR) redirected T cells are a potent treatment option for certain hematological malignancies. Recently, site-specific insertion of CARs into the T cell receptor (TCR) alpha constant ( TRAC ) locus using gene editing and adeno-associated viruses was shown to generate CAR T cells with improved functionality over their retrovirally transduced counterparts. However, the development of virus...

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Literature Corpus work: 5c86fa7f-9b19-507d-a9c7-56c28a36ad5c
DOI: 10.1101/2021.02.14.431017

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