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Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing

19 Mar 2019

Abstract excerpt

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematological and solid malignancies. However, despite the success of this field, there remain some major challenges, including accelerated T cell exhaustion, potential toxicities, and insertional oncogenesis. To overcome these limitations, recent advances in CRISPR technology have enabled targetable interventions of endogenous...

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PMID: 30941126
DOI: 10.3389/fimmu.2019.00456

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