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Article

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

9 Nov 2017

Abstract excerpt

T cells against a panel of established blood cancers and primary, patient-derived B-cell acute lymphoblastic leukemia blasts compared with standard TCR transfer. Our results suggest that TCR transfer combined with genome editing could lead to new, improved generations of cancer immunotherapies.

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Identifiers

PMID: 29122757
DOI: 10.1182/blood-2017-05-787598

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