Article

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

2024-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized the treatment of B cell malignancies and translating this success to other cancers remains an ongoing clinical objective. Next-generation T cell products in development aim to genetically modulate many facets of cell behavior, for which gene-nominating platforms provide a useful framework for prioritization. Among competing screen...

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Literature Corpus work: 483953fd-eb05-5918-9c59-2c218ccf4f03
DOI: 10.1101/2024.03.16.583115

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