Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cells

5 May 2025

Abstract excerpt

Genome-editing technologies have enabled the clinical development of allogeneic cellular therapies, yet the optimal gene-editing modality for multiplex editing of therapeutic T cell product manufacturing remains elusive. In this study, we conducted a comprehensive comparison of CRISPR/Cas9 nuclease and adenine base editor (ABE) technologies in generating allogeneic chimeric antigen receptor (CAR) T cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40324075
DOI: 10.1073/pnas.2427216122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quadruple adenine base–edited allogeneic CAR T cells outperform CRISPR/Cas9 nuclease–engineered T cellsPMID 40324075Read ↗

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALLSemantic proximity Read ↗

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editorsSemantic proximity Read ↗

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocationsSemantic proximity Read ↗

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editorsSemantic proximity Read ↗

Orthogonal CRISPR systems for targeted integration and multiplex base editing enable nonviral engineering of allogeneic CAR-T cellsSemantic proximity Read ↗

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editingSemantic proximity Read ↗

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell therapy applicationsSemantic proximity Read ↗

Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumorsSemantic proximity Read ↗

A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune CellsSemantic proximity Read ↗

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cellsSemantic proximity Read ↗

Applications of CRISPR Genome Editing to Advance the Next Generation of Adoptive Cell Therapies for CancerSemantic proximity Read ↗

Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.