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Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering

1 Jun 2021

Abstract excerpt

As genome engineering advances cell-based therapies, a versatile approach to introducing both CRISPR-Cas9 ribonucleoproteins (RNPs) and therapeutic transgenes into specific cells would be transformative. Autologous T cells expressing a chimeric antigen receptor (CAR) manufactured by viral transduction are approved to treat multiple blood cancers, but additional genetic modifications to alter cell programs will...

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PMID: 34077734
DOI: 10.1016/j.celrep.2021.109207

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