Article

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

2019-10-01

Abstract excerpt

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in Npc1 , resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, consequences of NPC1 loss on microglial function remain uncharacterized. Here, we provide an in-depth characterization of microglial proteomic signatures and phenotypes in a NPC1-deficient ( N...

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Literature Corpus work: a0268226-112d-57b6-8c9f-10250998a98e
DOI: 10.1101/789511

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