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Article

The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy.

Glia - 1 Jul 2020

Hamilton Noémie, Rutherford Holly A, Petts Jessica J, Isles Hannah M, Weber Thomas, Henneke Marco, Gärtner Jutta, Dunning Mark J, Renshaw Stephen A

Abstract excerpt

The contribution of microglia in neurological disorders is emerging as a leading disease driver rather than a consequence of pathology. RNAseT2-deficient leukoencephalopathy is a severe childhood white matter disorder affecting patients in their first year of life and mimicking a cytomegalovirus brain infection. The early onset and resemblance of the symptoms to a viral infection suggest an inflammatory and...

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PMID: 32212285
DOI: 10.1002/glia.23829
PMCID: PMC8647916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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