Article

Integrating human iPSC-derived macrophage progenitors into retinal organoids to generate a mature retinal microglial niche

2022-12-23

Abstract excerpt

In the retina, microglia are resident immune cells that are essential for retinal development and function. Retinal microglia play a central role in mediating pathological degeneration in diseases such as glaucoma, retinitis pigmentosa, age-related neurodegeneration, ischemic retinopathy and diabetic retinopathy. Current models of mature human retinal organoids (ROs) derived from iPS cell (hiPSC) do not contain re...

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Literature Corpus work: 42fe7d02-a37d-5488-8b1d-bd3c5e11568f
DOI: 10.1101/2022.12.23.521829

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