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Article

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

16 Jan 2023

Abstract excerpt

Microglia are the primary resident immune cells in the retina. They regulate neuronal survival and synaptic pruning making them essential for normal development. Following injury, they mediate adaptive responses and under pathological conditions they can trigger neurodegeneration exacerbating the effect of a disease. Retinal organoids derived from human induced pluripotent stem cells (hiPSCs) are increasingly...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 36644817
DOI: 10.1111/jcmm.17670

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