Article

Human iPSC-derived Microglial Cells Integrated into Mouse Retina and Recapitulated Features of Endogenous Microglia

2023-08-02

Abstract excerpt

Microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (CNS) disorders, including those affecting the retina. Replacing maladaptive microglia, such as those impacted by aging or over-activation, with exogenous microglia that can enable adaptive functions has been proposed as a potential therapeutic str...

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Literature Corpus work: 7f098b7e-9e59-5f72-b184-2cb58bafa502
DOI: 10.1101/2023.07.31.550858

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