Article

Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids

2024-09-21

Abstract excerpt

Prenatal immune challenges pose significant risks to human embryonic brain and eye development. However, we still lack knowledge about the safe usage of anti-inflammatory drugs during pregnancy. While human induced pluripotent stem cells (hIPSC)-derived brain organoid models have started to explore functional consequences upon viral stimulation, these models commonly lack microglia. Yet, microglia are susceptible...

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Literature Corpus work: 1a36e8b8-0f0e-5807-8d5b-d32642d8116b
DOI: 10.1101/2024.09.20.614136

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