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Article

Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy

20 Oct 2022

Abstract excerpt

Pathological angiogenesis is a major cause of irreversible blindness in individuals of all age groups with proliferative retinopathy (PR). Mononuclear phagocytes (MPs) within neovascular areas contribute to aberrant retinal angiogenesis. Due to their cellular heterogeneity, defining the roles of MP subsets in PR onset and progression has been challenging. Here, we aimed to investigate the heterogeneity of...

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PMID: 36264636
DOI: 10.1172/jci.insight.160940

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