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Article

A phylogenetic approach to inferring the order in which mutations arise during cancer progression.

PLoS computational biology - 1 Dec 2022

Gao Yuan, Gaither Jeff, Chifman Julia, Kubatko Laura

Abstract excerpt

Although the role of evolutionary process in cancer progression is widely accepted, increasing attention is being given to the evolutionary mechanisms that can lead to differences in clinical outcome. Recent studies suggest that the temporal order in which somatic mutations accumulate during cancer progression is important. Single-cell sequencing (SCS) provides a unique opportunity to examine the effect that the...

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Identifiers

PMID: 36459515
DOI: 10.1371/journal.pcbi.1010560
PMCID: PMC9750018

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