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Article

Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications.

BMC cancer - 1 Jul 2017

Sho Shonan, Court Colin M, Winograd Paul, Lee Sangjun, Hou Shuang, Graeber Thomas G, Tseng Hsian-Rong, Tomlinson James S

Abstract excerpt

BACKGROUND: Sequencing analysis of circulating tumor cells (CTCs) enables "liquid biopsy" to guide precision oncology strategies. However, this requires low-template whole genome amplification (WGA) that is prone to errors and biases from uneven amplifications. Currently, quality control (QC) methods for WGA products, as well as the number of CTCs needed for reliable downstream sequencing, remain poorly defined....

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Identifiers

PMID: 28666423
DOI: 10.1186/s12885-017-3447-6
PMCID: PMC5493892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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