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Article

Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies

2 Mar 2021

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a treatment-refractory malignancy in urgent need of a molecular framework for guiding therapeutic strategies. Bulk transcriptomic efforts over the past decade have yielded two broad consensus subtypes: classical pancreatic/epithelial versus basal-like/squamous/quasi-mesenchymal. Although this binary classification enables prognostic stratification, it does not currently...

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PMID: 33653818
DOI: 10.1158/1078-0432.ccr-20-4712

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