Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses.

FEBS letters - 1 Oct 2024

Cheung Hiu W, Schouw Alexander D, Altunay Zeynep M, Maddox J Wesley, Kresic Lyndsay C, McAllister Brenna C, Caro Keaven, Alam Shahnawaz, Huang Angie, Pijewski Robert S, Lee Amy, Martinelli David C

Abstract excerpt

C1QL1 is expressed in a subset of cells in the brain and likely has pleiotropic functions, including the regulation of neuron-to-neuron synapses. Research progress on C1QL proteins has been slowed by a dearth of available antibodies. Therefore, we created a novel knock-in mouse line in which an HA-tag is inserted into the endogenous C1ql1 locus. We examined the entire brain, identifying previously unappreciated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to Gene Knock-In Techniques

Share to Nerve Tissue Proteins

Share to Neurons

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 38858133
DOI: 10.1002/1873-3468.14946
PMCID: PMC11479844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detection at synapses.PMID 38858133Read ↗

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brainSemantic proximity Read ↗

Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.Semantic proximity Read ↗

Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brainSemantic proximity Read ↗

Genetic Disruption of WASHC4 Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and HumansSemantic proximity Read ↗

Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.Semantic proximity Read ↗

Cell-type specific visualization and biochemical isolation of endogenous synaptic proteins in miceSemantic proximity Read ↗

Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9Semantic proximity Read ↗

Cytoplasmic dynein heavy chain: the servant of many masters.Semantic proximity Read ↗

NCAM1 PolysialylationSemantic proximity Read ↗

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1.Semantic proximity Read ↗

The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescenceSemantic proximity Read ↗

Characterization of Endogenous and Epitope-Tagged Ubiquitin Expression and Ubiquitination Patterns at <i>Drosophila</i> Neuromuscular JunctionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.