Article

Young adult microglial deletion of C1q reduces engulfment of synapses and prevents cognitive impairment in an aggressive Alzheimer’s disease mouse model

2025-09-16

Abstract excerpt

C1q is a multifunctional protein, including its role as the initiating protein of the classical complement cascade. While classical pathway activation is involved in synaptic pruning during development of the nervous system, it also contributes to enhanced inflammation and cognitive decline in Alzheimer’s disease (AD). Constitutive genetic C1q deficiency has been shown to reduce glial activation and attenuate neur...

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Literature Corpus work: 120d146a-567a-5768-9029-1c8bad1607d5
DOI: 10.1101/2025.09.13.676049

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