Article

Neural Immunoglobulins Shape Brain Circuits

2025-09-15

Abstract excerpt

Mounting evidence is overturning the long-held dogma that antibodies enter the brain only through vascular leaks or blood–brain barrier disruption. Instead, neurons, astrocytes, and microglia themselves can generate restricted but functional immunoglobulin repertoires. This capacity arises through unconventional molecular processes including cryptic V(D)J recombination, splice-and-link RNA editing, and retroelemen...

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Literature Corpus work: ee5537dd-f71b-5f17-9142-7d9921fb9ee4
DOI: 10.22541/au.175792577.72130256/v1

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