Article

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice

2023-09-05

Abstract excerpt

<title>Abstract</title> Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human CD34+ HSCs and total body irradiation for adequate engraftment. Recently, we generated a NOG mouse strain with a point mutation in the c-kit tyro...

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Literature Corpus work: 42b6fd98-29f0-57e8-9fae-e154511b40cf
DOI: 10.21203/rs.3.rs-3267519/v1

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