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Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors

12 Dec 2012

Abstract excerpt

UNLABELLED: Better methods to characterize normal human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facilitate improving recovery rates in transplanted patients.We now show that 5-fold more human myeloid cells are produced in sublethally irradiated NOD/SCID-IL-2Receptor-γchain-null (NSG) mice engineered to constitutively produce human interleukin-3, granulocyte-macrophage...

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PMID: 23233660
DOI: 10.1182/blood-2012-09-456566

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