Article
Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source.
Frontiers in immunology - 1 Jan 2020
Hess Nicholas J, Lindner Payton N, Vazquez Jessica, Grindel Samuel, Hudson Amy W, Stanic Aleksandar K, Ikeda Akihiro, Hematti Peiman, Gumperz Jenny E
Abstract excerpt
NBSGW mice are highly immunodeficient and carry a hypomorphic mutation in the c-kit gene, providing a host environment that supports robust human hematopoietic expansion without pre-conditioning. These mice thus provide a model to investigate human hematopoietic engraftment in the absence of conditioning-associated damage. We compared transplantation of human CD34+ HSPCs purified from three different sources:...
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